1.5 billion people worldwide are affected by the intestinal parasitic worms soil-transmitted helminths (STHs).
STH infections are among the most common infections worldwide and affect the poorest and most vulnerable countries.
Moderate- to high-intensity STH infections reduce the body's ability to absorb nutrients and can lead to malnutrition, anaemia, impaired growth and cognitive development and increased susceptibility to infection, particularly in children.
The mission of the DeWorm3 project is to determine the feasibility of interrupting the transmission of three types of STHs:
- roundworm (Ascaris lumbricoides)
- hookworms (Necator americanus, Ancylostoma duodenate)
- whipworm (Trichuris trichiura).
The project will build on the success of programmes to eliminate lymphatic filariasis (also known as elephantiasis).
DeWorm3 is a five-year study with trial sites in Asia and east and west Africa, implemented in partnership with governments of endemic countries, research institutes and global disease experts.
The results of the elimination trials and accompanying implementation science research will provide the evidence to inform relevant guidelines, future policies and improve the lives of millions of people globally.