Anderson, R., et al. (2017). "Assessing the interruption of the transmission of human helminths with mass drug administration alone: optimizing the design of cluster randomized trials." Parasit Vectors 10(1): 93.
A method is outlined for the use of an individual-based stochastic model of parasite transmission dynamics to assess different designs for a cluster randomized trial in which mass drug administration (MDA) is employed in attempts to eliminate the transmission of soil-transmitted helminths (STH) in defined geographic locations.
This review summarizes the prospects for switching from control to an elimination strategy.
Werkman, M., et al. (2017). "The past matters: estimating intrinsic hookworm transmission intensity in areas with past mass drug administration to control lymphatic filariasis." Parasit Vectors 10(1): 254.
To design the optimal MDA intervention to eliminate STH infections, it is vital to have information on historical MDA programmes and baseline prevalence to estimate the intrinsic transmission intensity for the defined setting (R0).
We develop a simulation of an elimination study, based on the DeWorm3 project, using an individual- based stochastic disease transmission model in conjunction with models of MDA, sampling, diagnostics and the construction of study clusters. The simulation is then used to analyse the relationship between the study end-point elimination threshold and whether elimination is achieved in the long term within the model.
Farrell, S. H., et al. (2017). "The importance of patient compliance in repeated rounds of mass drug administration (MDA) for the elimination of intestinal helminth transmission." Parasit Vectors 10(1): 291.
Here we develop an individual-based stochastic model of helminth transmission and MDA treatment to investigate how different patterns of compliance influence the impact of MDA for two groups of helminths, the soil transmitted nematode infections and the schistosome parasites.
Means, A. R., et al. (2016). "Sustaining progress towards NTD elimination: an opportunity to leverage lymphatic filariasis elimination programs to interrupt transmission of soil-transmitted helminths." PLoS Negl Trop Dis 10(7): e0004737.
We identify specific rationale, opportunities, and challenges associated with leveraging existing LF elimination platforms for the purpose of interrupting STH transmission.
Truscott, J. E., et al. (2016). "Soil-transmitted helminths: mathematical models of transmission, the impact of mass drug administration and transmission elimination criteria." Adv Parasitol 94: 133-198.
In this chapter, we review the underlying biology and epidemiology of the three causative intestinal nematode species that are mostly considered under the STH umbrella term. We review efforts to model the transmission cycle of these helminths in populations and the effects of preventative chemotherapy on their control and elimination.